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KMID : 0882420150890040452
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Korean Journal of Medicine
2015 Volume.89 No. 4 p.452 ~ p.456
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A Case of Mycobacterium gordonae Pulmonary Disease in a Patient with Ulcerative Colitis Treated with Infliximab
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Choi Ji-Sung
Bae Jong-Wook
Lee Sang-Won
Choi Gyu-Ho
Shin Jeong-Eun
Myung Na-Hye
Park Jae-Seuk
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Abstract
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Tumor necrosis factor-α (TNF-α) is a key component of the host defense against mycobacterial infection.Mycobacterium gordonae (M. gordonae) is one of the least virulent mycobacteria, and is generally considered non-pathogenic if detected from a clinical specimen. Here, we report a rare case of pulmonary M. gordonae infection in a patient with ulcerative colitis who had been treated with infliximab, a TNF-α antagonist. M. gordonae infection was treated successfully with clarithromycin, rifampin, and ethambutol. We believe this to be the first report of M. gordonae pulmonary disease associated with TNF-α antagonist treatment.
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KEYWORD
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Mycobacterium gordonae, Ulcerative colitis, Infliximab, Tumor necrosis factor-alpha
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